Phenotypes Associated with This Genotype

Genotype
MGI:3616189

• Allelic Composition: Apoe^{tm1(APOE_i4)Sfu}/Apoe^{tm1(APOE_i4)Sfu}
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating cholesterol level ( J:104859 )

• serum cholesterol level is increased relative to knock-ins expressing apoE2 or apoE3

abnormal response to CNS ischemic injury ( J:104859 )

• 24 hours after ischemic injury, mice have significantly greater neurologic scores than human APOE2- or APOE3-expressing mice, suggesting poorer outcome

• total infarct area is significantly larger than in knock-ins expressing human APOE2 or APOE3

nervous system

abnormal response to CNS ischemic injury ( J:104859 )

• 24 hours after ischemic injury, mice have significantly greater neurologic scores than human APOE2- or APOE3-expressing mice, suggesting poorer outcome

• total infarct area is significantly larger than in knock-ins expressing human APOE2 or APOE3

cellular

abnormal plasma membrane morphology ( J:103515 )

• abnormal transbilayer distribution of synaptic plasma membrane cholesterol, with a 2-fold increase in exofacial leaflet cholesterol and a reduction in cytofacial leaflet cholesterol, however total amounts of synaptic plasma membrane cholesterol levels were not different from wild-type