Phenotypes Associated with This Genotype

Genotype
MGI:3615763

• Allelic Composition: Rad50^tm1Jpt/Rad50^tm1Jpt
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Development of Rad50^tm1Jpt/Rad50^tm1Jpt embryos

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:56083 )

• embryos become abnormal by E6 and are largely resorbed by E7.5 and E8.5

growth/size/body

decreased embryo size ( J:56083 )

• some embryos between E6 and E8.5 are significantly smaller than wild-type, however no morphological abnormalities are seen at E5.5

embryo

abnormal developmental patterning ( J:56083 )

• in the small E6 embryos, endodermal and ectodermal cells are packed loosely and appear not to form the normal columnar ectoderm

embryonic growth arrest ( J:56083 )

• some E6.5 embryos have recognizable embryonic tissues but they are not developed appreciably and resemble E6 embryos both in size and degree of germ-layer differentiation

decreased embryo size ( J:56083 )

• some embryos between E6 and E8.5 are significantly smaller than wild-type, however no morphological abnormalities are seen at E5.5

cellular

increased cellular sensitivity to gamma-irradiation ( J:56083 )

• blastocyst explants exhibit increased sensitivity to gamma-irradiation, with only the nonmitotic trophoblast giant cells remaining viable after irradiation

decreased cell proliferation ( J:56083 )

• E6.5 embryos exhibit a decrease in the number of proliferating cells but no differences in the levels of apoptosis