Phenotypes Associated with This Genotype

Genotype
MGI:3615687

• Allelic Composition: Rad50^tm2Jpt/Rad50^tm2Jpt; Smc1a^tm1Mbk/Smc1a^tm1Mbk
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:103922 )

♀ • double homozygotes are indistinguishable from homozygous Rad50^tm2Jpt mice with respect to survival and die within 5 months after birth

hematopoietic system

abnormal hematopoietic system morphology/development ( J:103922 )

♀ • double homozygotes are indistinguishable from homozygous Rad50 mice with respect to hematopoietic cell numbers

abnormal pro-B cell morphology ( J:103922 )

♀ • pro-B cell numbers are similar to that in homozygous Rad50 mice

decreased double-negative T cell number ( J:103922 )

♀ • double-negative T cell numbers are similar to that in homozygous Rad50 mice

anemia ( J:103922 )

♀ • 26 of 27 develop anemia

decreased macrophage cell number ( J:103922 )

♀ • macrophage numbers are similar to that in homozygous Rad50 mice

immune system

abnormal pro-B cell morphology ( J:103922 )

♀ • pro-B cell numbers are similar to that in homozygous Rad50 mice

decreased double-negative T cell number ( J:103922 )

♀ • double-negative T cell numbers are similar to that in homozygous Rad50 mice

decreased macrophage cell number ( J:103922 )

♀ • macrophage numbers are similar to that in homozygous Rad50 mice