Phenotypes Associated with This Genotype

Genotype
MGI:3615685

• Allelic Composition: Chek2^tm1Mak/Chek2⁺; Rad50^tm2Jpt/Rad50^tm2Jpt
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:103922 )

• 31 of 41 die by 5 months of age

hematopoietic system

abnormal pro-B cell morphology ( J:103922 )

• pro-B cell numbers are similar to that in homozygous Rad50^tm2Jpt mice

decreased double-negative T cell number ( J:103922 )

• double-negative T cell numbers are similar to that in homozygous Rad50^tm2Jpt mice

anemia ( J:103922 )

• 36 of 41 develop anemia

decreased macrophage cell number ( J:103922 )

• macrophage numbers are similar to that in homozygous Rad50^tm2Jpt mice

immune system

abnormal pro-B cell morphology ( J:103922 )

• pro-B cell numbers are similar to that in homozygous Rad50^tm2Jpt mice

decreased double-negative T cell number ( J:103922 )

• double-negative T cell numbers are similar to that in homozygous Rad50^tm2Jpt mice

decreased macrophage cell number ( J:103922 )

• macrophage numbers are similar to that in homozygous Rad50^tm2Jpt mice