Phenotypes Associated with This Genotype

Genotype
MGI:3615684

• Allelic Composition: Chek2^tm1Mak/Chek2^tm1Mak; Rad50^tm2Jpt/Rad50^tm2Jpt
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:103922 )

• 13 of 65 die by 5 months of age, however survival time is increased compared to homozygous Rad50^tm2Jpt mice, as 52 mutants survive past 5 months of age and none develop anemia

neoplasm

increased lymphoma incidence ( J:103922 )

• 10 of 65 mice develop lymphoma

hematopoietic system

hematopoietic system phenotype ( J:103922 )

N • exhibit hematopoietic rescue of the abnormalities seen in homozygous Rad50^tm2Jpt mice, with numbers of double-negative T cells, pro-B cells, and macrophages within 2-fold levels of wild-type levels