Phenotypes for Mre11a Rad50 MGI:3615680 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mre11a^tm1Jpt/Mre11a⁺ Rad50^tm2Jpt/Rad50^tm2Jpt
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mre11a^tm1Jpt mutation (1 available); any Mre11a mutation (49 available)
Rad50^tm2Jpt mutation (0 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:103922 )

• 32 of 49 die before 5 months of age, however survival time is increased compared to homozygous Rad50^tm2Jpt mice, as 17 mutants survive past 5 months of age

hematopoietic system

abnormal hematopoietic system morphology/development ( J:103922 )

• 19 of the 32 mutants that die exhibited hematopoietic attrition

anemia ( J:103922 )

• 19 of the 32 mutants that die exhibit anemia

neoplasm

increased lymphoma incidence ( J:103922 )

• 10 of the 32 mutants that die succumb to lymphoma

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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