Phenotypes Associated with This Genotype

Genotype
MGI:3615671

• Allelic Composition: Mre11a^tm1Jpt/Mre11a^tm1Jpt; Rad50^tm2Jpt/Rad50^tm2Jpt
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:103922 )

• although some die prematurely, survival time is increased compared to homozygous Rad50^tm2Jpt mice, with 24 of 29 alive at 5 months of age with no signs of anemia

neoplasm

increased lymphoma incidence ( J:103922 )

• 4 of 24 develop lymphoma

cellular

abnormal cell cycle checkpoint function ( J:103922 )

• MEFs exhibit defects in G1/S, intra-S-phase, and G2/M checkpoints after ionizing radiation induced DNA damage

increased cellular sensitivity to ionizing radiation ( J:103922 )

• MEFs exhibit increased sensitivity to ionizing radiation

chromosome breakage ( J:103922 )

hematopoietic system

hematopoietic system phenotype ( J:103922 )

N • do not observe hematopoietic cell attrition as in homozygous Rad50 mice, indicating rescue of hematopoietic defects