Phenotypes Associated with This Genotype

Genotype
MGI:3615670

• Allelic Composition: Rad50^tm2Jpt/Rad50^tm2Jpt
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:103922 )

• most die during the first 5 months of age

hematopoietic system

decreased pro-B cell number ( J:103922 )

• decrease in pro-B cell numbers

decreased double-negative T cell number ( J:103922 )

anemia ( J:103922 )

• 82 of 83 die with anemia

abnormal bone marrow cell morphology/development ( J:103922 )

• increase in apoptosis in the bone marrow as indicated by increased levels of cleaved Caspase-3

thrombocytopenia ( J:103922 )

decreased macrophage cell number ( J:103922 )

pancytopenia ( J:103922 )

• peripheral blood cell numbers are decreased (32% vs. 41% in wild-type)

immune system

decreased pro-B cell number ( J:103922 )

• decrease in pro-B cell numbers

decreased double-negative T cell number ( J:103922 )

decreased macrophage cell number ( J:103922 )

neoplasm

increased lymphoma incidence ( J:103922 )

• 1 of 83 die with lymphoma