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Phenotypes Associated with This Genotype
Genotype
MGI:3615669
Allelic
Composition		 Atmtm1Awb/Atm+
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (167 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:103922 )
• although most succumb to anemia, they have a significantly greater survival time than homozygous Rad50tm2Jpt mice, with 85% living longer than 5 months of age

neoplasm
increased lymphoma incidence ( J:103922 )
• 16 of 67 develop lymphoma

hematopoietic system
anemia ( J:103922 )
• most succumb to anemia
decreased macrophage cell number ( J:103922 )
• macrophage counts are decreased to a similar level as in homozygous Atmtm1Awb mice

immune system
decreased macrophage cell number ( J:103922 )
• macrophage counts are decreased to a similar level as in homozygous Atmtm1Awb mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory