About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3615669
Allelic
Composition		 Atmtm1Awb/Atm+
Rad50tm2Jpt/Rad50tm2Jpt
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Awb mutation (7 available); any Atm mutation (168 available)
Rad50tm2Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:103922 )
• although most succumb to anemia, they have a significantly greater survival time than homozygous Rad50tm2Jpt mice, with 85% living longer than 5 months of age

neoplasm
increased lymphoma incidence ( J:103922 )
• 16 of 67 develop lymphoma

hematopoietic system
anemia ( J:103922 )
• most succumb to anemia
decreased macrophage cell number ( J:103922 )
• macrophage counts are decreased to a similar level as in homozygous Atmtm1Awb mice

immune system
decreased macrophage cell number ( J:103922 )
• macrophage counts are decreased to a similar level as in homozygous Atmtm1Awb mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory