Phenotypes Associated with This Genotype

Genotype
MGI:3615663

• Allelic Composition: Atm^tm1Awb/Atm^tm1Awb; Rad50^tm2Jpt/Rad50^tm2Jpt
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:103922 )

• although die of malignancy, they have a significantly greater survival time than homozygous Rad50^tm2Jpt mice, with 42% living longer than 5 months, 20.5% surviving to 10 months and 18% surviving to 15 months

neoplasm

increased lymphoma incidence ( J:103922 )

• although mutants develop lymphomas, the latency of lymphomagenesis is increased compared to homozygous Atm^tm1Awb mice

cellular

cellular phenotype ( J:103922 )

N • growth of MEFs and sensitivity to irradiation is comparable to wild-type indicating rescue of the slower growth of MEFs and increased sensitivity to gamma-irradiation that is seen in homozygous Atm^tm1Awb mice

abnormal cell cycle checkpoint function ( J:103922 )

• MEFs exhibit defects in G1/S, intra-S-phase, and G2/M checkpoints after ionizing radiation induced DNA damage

chromosome breakage ( J:103922 )

• exhibit some chromosomal instability, however it is slightly reduced relative to homozygous Atm mice

hematopoietic system

anemia ( J:103922 )

• 4 of 42 develop anemia