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Phenotypes Associated with This Genotype
Genotype
MGI:3615659
Allelic
Composition		 Sstr2tm1Bne/Sstr2tm1Bne
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sstr2tm1Bne mutation (0 available); any Sstr2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:75873 )
N
• homozygotes display no significant differences in jejunal contractile activity, as shown by normal migrating motor complex properties (MMCs) evoked by distension (intraluminal pressure 2.5-3.5 cmH2O) relative to wild-type mice
• notably, both agonist BIM-23027 and SRIF (somatotropin release-inhibitory factor) significantly increase the interval between MMCs in wild-type jejunum, but only SRIF is effective in mutant jejunum, indicating that an additional receptor subtype is involved in the regulation of intestinal peristalsis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory