Phenotypes Associated with This Genotype

Genotype
MGI:3615575

• Allelic Composition: Hmgb2^tm1Meb/Hmgb2^tm1Meb
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

teratozoospermia ( J:67968 )

♂ • structurally abnormal sperm

multinucleated giant male germ cells ( J:67968 )

♂

asthenozoospermia ( J:67968 )

♂ • more than 95% of sperm are non motile

reproductive system

teratozoospermia ( J:67968 )

♂ • structurally abnormal sperm

multinucleated giant male germ cells ( J:67968 )

♂

asthenozoospermia ( J:67968 )

♂ • more than 95% of sperm are non motile

abnormal testis morphology ( J:67968 )

♂

abnormal seminiferous tubule morphology ( J:67968 )

♂ • histological abnormalities in organization after 30 days of age

♂ • becomes more serious with advancing age

♂ • loss of regular periphery to lumen progression of spermatogonia, spermatocytes, spermatids and spermatozoa

♂ • gaps among cells

♂ • increased levels of apoptosis

abnormal Sertoli cell morphology ( J:67968 )

♂ • degenerated Sertoli cells

cryptorchism ( J:67968 )

♂ • failure of testes to descend in about 1/3 of homozygous males although testis size normal

♂ • testes descended in older males

reduced male fertility ( J:67968 )

♂

endocrine/exocrine glands

abnormal testis morphology ( J:67968 )

♂

abnormal seminiferous tubule morphology ( J:67968 )

♂ • histological abnormalities in organization after 30 days of age

♂ • becomes more serious with advancing age

♂ • loss of regular periphery to lumen progression of spermatogonia, spermatocytes, spermatids and spermatozoa

♂ • gaps among cells

♂ • increased levels of apoptosis

abnormal Sertoli cell morphology ( J:67968 )

♂ • degenerated Sertoli cells

cryptorchism ( J:67968 )

♂ • failure of testes to descend in about 1/3 of homozygous males although testis size normal

♂ • testes descended in older males