Phenotypes Associated with This Genotype

Genotype
MGI:3615488

• Allelic Composition: Gnat3^tm1Rfm/Gnat3^tm1Rfm
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

taste/olfaction

abnormal taste sensitivity ( J:36885 )

• homozygotes exhibit normal taste epithelia, with no significant differences in the three types of taste papillae, number of taste buds in each papilla or complement of taste receptor cells per bud relative to wild-type mice

• homozygotes display normal responses to a range of salty (NaCl) and sour (HCl) solutions

• notably, although the electrophyiological (chorda tympani) response is greater for sweet than for bitter compounds, the aversive behavioral effect is greater with bitter compounds

abnormal bitter taste sensitivity ( J:36885 )

• homozygotes exhibit reduced aversive behavioral and electrophysiological responses to bitter compounds (denatorium and quinine) relative to wild-type mice

abnormal sweet taste sensitivity ( J:36885 )

• homozygotes also exhibit reduced behavioral and electrophysiological responses to sweet compounds (sucrose and sweetener SC45647) relative to wild-type mice

abnormal umami taste sensitivity ( J:92635 )

• reduced preference for MSG at concentrations normally preferred by control mice