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Phenotypes Associated with This Genotype
Genotype
MGI:3615463
Allelic
Composition
Osr1tm1Jian/Osr1tm1Jian
Genetic
Background
either: (involves: 129S1/Sv * C57BL/6J) or (involves: 129S1/Sv * ICR)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Osr1tm1Jian mutation (1 available); any Osr1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mutants embryos die between 11.5 and 12.5

embryo
• at E12, yolk sac lacks blood circulation
• a hypoplastic gonadal ridge is noted at E11.5
• at E11.5, fewer mesonephric tubules are observed and the gonadal ridge is retarded
• at E11.5, the Wolffian duct is often malformed or absent in the posterior trunk region
• significantly fewer mesonephric vesicles are noted at E10.5
• Wolffian duct development is already disrupted at E9.5
• at E10.5, disrupted or posteriorly truncated Wolffian ducts are observed
• the Wolffian duct defect is always more severe on the left side than on the right side such that the left duct is often truncated posteriorly

homeostasis/metabolism
• embryos at late gestation show generalized edema

cardiovascular system
• at E12, yolk sac lacks blood circulation
• at E11.5, embryos have hypoplastic venous valves
• at E15.5, atrioventricular junction is malformed
• septum primum does not form
• at E15.5, embryos lack a primary atrial septum
• at E11.5, the atria were severely dilated
• later embryos have dilated atria
• at E15.5, ventricular septum is malformed
• at E15.5, mesothelium fails to form complete parietal pericardium
• at E12, embryos have pooled blood in the liver and major veins
• at E11.5, blood backflow from the heart into the inflow tract is observed

renal/urinary system
• at E10.5, massive cell death is noted in the nephrogenic mesenchyme
• at E10.5 to E11.5, mutant embryos fail to initiate metanephric kidney formation
• at E10.5 to E11.5, no signs of metanephric mesenchyme condensation is observed
• at E10.5, massive cell death is noted in the nephrogenic mesenchyme
• at E15.5, all mutant embryos lack metanephric kidneys
• as a result, internal organs (e.g. pancreas and spleen) are displaced but remain morphologically normal
• at E10.5 to E11.5, ureteric bud formation is absent

endocrine/exocrine glands
• at E15.5-E17.5, all surviving mutants lack gonads

reproductive system
• at E15.5-E17.5, all surviving mutants lack gonads

respiratory system
• at E15.5, lung tissue is observed as a compressed mass

cellular
• at E10.5, massive cell death is noted in the nephrogenic mesenchyme


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory