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Phenotypes Associated with This Genotype
Genotype
MGI:3615446
Allelic
Composition		 Polhtm1.1Rak/Polh+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm1.1Rak mutation (1 available); any Polh mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased skin tumor incidence ( J:105034 )
• increased susceptibility over wild-type to develop skin tumors
increased incidence of tumors by UV-induction ( J:105034 )
• increased incidence several months after UV-irradiation

integument
increased skin tumor incidence ( J:105034 )
• increased susceptibility over wild-type to develop skin tumors

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory