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Phenotypes Associated with This Genotype
Genotype
MGI:3615358
Allelic
Composition
Trak1hyrt/Trak1hyrt
Genetic
Background
involves: AKR * C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trak1hyrt mutation (1 available); any Trak1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some deaths among adolescent mice but most have normal life spans

behavior/neurological
• slight tremors
• first noticeable at 2 weeks of age
• first noticeable at 2 weeks of age
• first noticeable at 2 weeks of age
• stiff gait
• first noticeable at 2 weeks of age

muscle
• highly elevate baseline motor unit activity in muscles of both forelimb and hind limb
• motor unit activity reduced by diazepam which enhances GABAergic transmission

nervous system
• oval shaped aggregates of vescicular structures with 2-layer membranes in the gray matter of brainstem and spinal cord
• inclusions found in neuronal processes only, possibly in dendrites
• become detectable at 2-4 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Stiff-Person syndrome DOID:13366 OMIM:184850
J:105231


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory