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Phenotypes Associated with This Genotype
Genotype
MGI:3615357
Allelic
Composition
Lrp5tm1Grw/Lrp5tm1Grw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1Grw mutation (1 available); any Lrp5 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Bone phenotype of Lrp5tm1Grw/Lrp5tm1Grw mice

cellular
• osteoblast function is diminished

skeleton
• osteoblast function is diminished
• decrease in osteoclast number in secondary spongiosa
• decrease in total bone mineral density, trabecular bone mineral density, trabecular thickness, trabecular number, mineralizing surface, and mineral apposition rate (J:104382)
• lithium chloride treatment improves bone formation in homozygotes (J:104382)
• female mice treated with a sclerostin antibody show improvement in bone properties and bone formation (J:213541)
• osteoblast number is reduced
• decrease in trabecular bone mineral density, trabecular thickness, and trabecular number
• reduction in bone mass because of a deficiency in osteoblast number and function (J:104382)
• decrease in mineral apposition rate and mineralizing surface (J:104382)
• mineral apposition rates and bone formation rates are decreased (J:213541)
• mineralizing surface per unit bone surface is reduced in femurs (J:213541)
• decrease in bone formation rate
• bones show decreased ultimate force, energy to failure, and stiffness, indicating decreased bone strength

hematopoietic system
• decrease in osteoclast number in secondary spongiosa

immune system
• decrease in osteoclast number in secondary spongiosa

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
osteoporosis-pseudoglioma syndrome DOID:0060849 OMIM:259770
J:213541


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory