Phenotypes Associated with This Genotype

Genotype
MGI:3615302

• Allelic Composition: Olig2^tm1Qrlu/Olig2^tm1Qrlu; Tg(GFAP-cre)25Mes/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb grasping ( J:105071 )

• abnormal limb clasping reflex

• beginning at 2 weeks of age

tremors ( J:105071 )

• beginning at 2 weeks of age

nervous system

abnormal oligodendrocyte morphology ( J:105071 )

• development arrested in dorsal cortex before formation of cells capable of forming myelin

abnormal corpus callosum morphology ( J:105071 )

• severe reduction in numbers of myelinated axons and myelin sheaths are thinner

cellular

abnormal oligodendrocyte morphology ( J:105071 )

• development arrested in dorsal cortex before formation of cells capable of forming myelin