Analysis Tools
muscle
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• heart triglyceride content of 28 day old homozygous mice is significantly elevated
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mortality/aging
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• most homozygotes die by 6 weeks of age; the longest survivor lived 30 weeks
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growth/size/body
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• at 28 days of age, hearts of homozygous mice are enlarged 2- to 3-fold relative to body weight in comparison to those of both wild-type and hemizygous mice
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• at 28 days of age, the weight of homozygous mice is only about two-thirds that of wild-type or hemizygous mice
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• by 1 day of age, homozygotes exhibit swollen abdomens due to extreme hepatomegaly
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• at 28 days of age, livers of homozygous mice are enlarged more than two-fold, relative to body weight, compared to those of wild-type or hemizygous mice
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liver/biliary system
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• by 1 day of age, homozygotes exhibit swollen abdomens due to extreme hepatomegaly
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• at 28 days of age, livers of homozygous mice are enlarged more than two-fold, relative to body weight, compared to those of wild-type or hemizygous mice
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• hepatic total cholesterol is only slightly raised relative to that of wild-type and hemizygous mice
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• liver triglyceride content of 28 day old homozygotes is dramatically elevated, approximately 5-fold
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• microscopic examination of stained liver sections from chow-fed 28 day old homozygotes reveals cytosolic accumulation of lipid
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pale liver
(
J:60187
)
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• livers of chow-fed 28 day old homozygous mice appear pale
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homeostasis/metabolism
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• heart triglyceride content of 28 day old homozygous mice is significantly elevated
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• carnitine levels are reduced more than 4-fold in plasma of homozygotes relative to wild-type mice
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• plasma free fatty acid levels of 28 day old homozygous mice are greatly elevated - approximately 5-fold - compared to those of wild-type and hemizygous mice
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• plasma triglyceride levels of 28 day old homozygotes are dramatically elevated - up to 10-fold - relative to those of wild-type and hemizygous mice
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• the excess plasma triglycerides of homozygous mice are largely confined to the very low density lipoprotein (VLDL) fraction [TAS]
• timed plasma triglyceride measurements under conditions of impaired lipolysis and VLDL triglyceride clearance demonstrate approximately 3-fold higher rates of hepatic VLDL triglyceride secretion in homozygous mice than in wild-type mice; untreated homozygous mice have normal hepatic and lipoprotein lipase activities and hepatic VLDL triglyceride clearance
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• total cholesterol in homozygous hearts is only slightly raised compared to measurements for wild-type and hemizygous mice
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• hepatic total cholesterol is only slightly raised relative to that of wild-type and hemizygous mice
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• liver triglyceride content of 28 day old homozygotes is dramatically elevated, approximately 5-fold
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cardiovascular system
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• heart triglyceride content of 28 day old homozygous mice is significantly elevated
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• at 28 days of age, hearts of homozygous mice are enlarged 2- to 3-fold relative to body weight in comparison to those of both wild-type and hemizygous mice
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