Phenotypes Associated with This Genotype

Genotype
MGI:3614660

• Allelic Composition: Nkx6-1^tm1Jlr/Nkx6-1^tm1Jlr
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:64376 )

• homozygotes are born at the expected Mendelian frequency but die soon after birth

nervous system

decreased motor neuron number ( J:64376 )

• homozygotes show a significant reduction in motor neuron generation

abnormal neuron specification ( J:64376 )

• homozygotes show a dorsal-to-ventral switch in the identity of progenitors and in the fate of postmitotic neurons, with a complete block in the generation of V2 interneurons and motor neurons and a compensatory ventral expansion in the domain of generation of V1 neurons

abnormal ventral interneuron 1 morphology ( J:64376 )

• homozygotes exhibit a significant reduction in the generation of V2 interneurons along with a compensatory ventral expansion in the generation of a more dorsal V1 neuronal subtype

abnormal ventral interneuron 2 morphology ( J:64376 )

• homozygotes exhibit a significant reduction in the generation of V2 interneurons along with a compensatory ventral expansion in the generation of a more dorsal V1 neuronal subtype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:64376 )

• homozygotes display movements only upon tactile stimulation