Mouse Genome Informatics
hm
    Kiss1rtm1Gstn/Kiss1rtm1Gstn
involves: 129P2/OlaHsd
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• examination of homozygous embryos at 16.5 dpc shows no differences in the development of the reproductive organs compared to wild-type suggesting that the appearance of the following phenotypes at 7 weeks of age is a postnatal event
• reduced in size or not found due to small size
• hypoplasia of uterine horns
• reduced in size or not found due to small size
• frequently absent
• 17% reduction in testis weight

growth/size/body
• males exhibit lower body weight than controls

immune system
• higher thymus/body weight ratio

renal/urinary system
• frequently absent
• reduced kidney/body weight ratio

endocrine/exocrine glands
• frequently absent
• 17% reduction in testis weight
• higher thymus/body weight ratio

hematopoietic system
• higher thymus/body weight ratio

integument
• frequently absent

Mouse Models of Human Disease
OMIM IDRef(s)
Hypogonadotropic Hypogonadism 8 with or without Anosmia; HH8 614837 J:102113