Phenotypes Associated with This Genotype

Genotype
MGI:3614421

• Allelic Composition: Drd3^tm1Dac/Drd3⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased exploration in new environment ( J:32128 )

• heterozygotes exhibit increased exploratory behavior in the open field, with a degree of hyperactivity comparable to than of homozygotes during the last 11 min of a 15-min test

decreased grooming behavior ( J:32128 )

• heterozygotes tend to show reduced grooming behavior with a delayed onset; however, these differences are not statistically significant relative to wild-type grooming behavior

abnormal locomotor activation ( J:96229 )

• during the first part of the test (increased early and decreased late) unlike wild-type mice

hyperactivity ( J:32128 , J:96229 )

• in the open field test, heterozygotes display hyperactivity, as shown by a 38% increase in locomotor activity (crossings) relative to wild-type mice (J:32128)

• during the first part of the test (J:96229)

increased vertical activity ( J:32128 , J:96229 )

• in the open field test, heterozygotes display 77% more rearing episodes than wild-type mice (J:32128)

• during the first part of the test (J:96229)

cardiovascular system

increased systemic arterial diastolic blood pressure ( J:115136 )

• after anesthesia with pentobarbital

increased systemic arterial systolic blood pressure ( J:115136 )

• after anesthesia with pentobarbital

homeostasis/metabolism

increased renin activity ( J:115136 )