Phenotypes Associated with This Genotype

Genotype
MGI:3614420

• Allelic Composition: Drd3^tm1Dac/Drd3^tm1Dac
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to morphine ( J:103701 )

• mice exhibit decreased morphine-induced conditioned place preference (CPP) compared with similarly treated wild-type mice

• BP 897-treated mice fail to exhibit a decrease in morphine-induced CPP compared with similarly treated wild-type mice

impaired conditioned place preference behavior ( J:103701 )

• mice exhibit decreased morphine-induced conditioned place preference (CPP) compared with similarly treated wild-type mice

• BP 897-treated mice fail to exhibit a decrease in morphine-induced CPP compared with similarly treated wild-type mice

increased exploration in new environment ( J:32128 )

• homozygotes exhibit increased exploratory behavior in the open field test

• in contrast, normal gait, coordination and primitive reflexes remain intact

decreased grooming behavior ( J:32128 )

• homozygotes tend to show reduced grooming behavior with a delayed onset; however, these differences are not statistically significant relative to wild-type grooming behavior

hyperactivity ( J:32128 )

• in the open field test, homozygotes display hyperactivity, as shown by a 57% increase in locomotor activity (crossings) relative to wild-type mice

increased vertical activity ( J:32128 )

• in the open field test, homozygotes display 93% more rearing episodes than wild-type mice

cardiovascular system

decreased systemic arterial systolic blood pressure ( J:115136 )

• systolic blood pressure in losartan-treated mice remains depressed longer than similarly treated wild-type mice

increased systemic arterial diastolic blood pressure ( J:115136 )

• after anesthesia with pentobarbital

increased systemic arterial systolic blood pressure ( J:115136 )

• after anesthesia with pentobarbital

homeostasis/metabolism

decreased urine sodium level ( J:115136 )

• after acute saline loading

increased renin activity ( J:115136 )

• in the kidneys

abnormal physiological response to xenobiotic ( J:115136 )

• systolic blood pressure in losartan-treated mice remains depressed longer than similarly treated wild-type mice

renal/urinary system

decreased urine sodium level ( J:115136 )

• after acute saline loading

decreased urine flow rate ( J:115136 )

• after acute saline loading, urine flow is decreased compared to in wild-type mice