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Phenotypes Associated with This Genotype
Genotype
MGI:3614341
Allelic
Composition
Tg(MMTV-PyVT*Y250F)250-2Mul/?
Genetic
Background
FVB/N-Tg(MMTV-PyVT*Y250F)250-2Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• female specific phenotype, global induction of well-defined alveolar hyperplasia in 12-week-old virgin animals
• the mammary epithelium were incapable of nursing
• female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance
• compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors
• the tumors were focal in origin and contain a large stromal component

neoplasm
• female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance
• compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors
• the tumors were focal in origin and contain a large stromal component

integument
• female specific phenotype, global induction of well-defined alveolar hyperplasia in 12-week-old virgin animals
• the mammary epithelium were incapable of nursing
• female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance
• compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors
• the tumors were focal in origin and contain a large stromal component

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:56327


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory