Mouse Genome Informatics
tg
    Tg(MMTV-PyVT*Y250F)250-2Mul/?
FVB/N-Tg(MMTV-PyVT*Y250F)250-2Mul
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• female specific phenotype, global induction of well-defined alveolar hyperplasia in 12-week-old virgin animals
• the mammary epithelium were incapable of nursing

tumorigenesis
• female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance
• compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors
• the tumors were focal in origin and contain a large stromal component

integument
• female specific phenotype, global induction of well-defined alveolar hyperplasia in 12-week-old virgin animals
• the mammary epithelium were incapable of nursing

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:56327