Phenotypes for Sim1 Sim2 MGI:3613784 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Sim1^tm1Jlmd/Sim1^tm1Jlmd Sim2^tm1Fan/Sim2^tm1Fan
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1^tm1Jlmd mutation (0 available); any Sim1 mutation (52 available)
Sim2^tm1Fan mutation (0 available); any Sim2 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system tract morphology ( J:104419 )

• at E18.5, the principal mammillary axonal tract and mammilothalmic tract are absent

• on the mammillary body in the location of the principal mammillary axonal tract a group of ectopic axons is seen and at the most posterior level of the mammillary body these axons cross the midline ventrocaudally to the third ventricle

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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