Analysis Tools
mortality/aging
nervous system
| N |
• PVN/SON progenitors are generated and differentiate normally in mutant mice
|
|
• by E12.5, a subtle but noticeable difference in the shape of the paraventricular nucleus/supraoptic nucleus (PVN/SON) progenitor domains is observed between mutants and controls
• at E13.5, mutant cells are never found at the lateral pia surface
• at E14.5 when normal PVN and SON neurons are distinguishable in controls, mutant cells are less coherent and stay as a scattered group of cells between normal PVN and SON positions
• at E15.5, mutant cells remain mislocalized
• at P0, no mutant cells are found at normal PVN or SON positions
|
|
• severe defects of the paraventricular, supraoptic and anterior paraventricular nuclei are seen
(J:104419)
• a slight dorsal shift of the hypothalamic Dlx1 domain is observed
(J:120909)
|
|
• at E18.5, the principal mammillary axonal tract appears less prominent and contains additional axons originating laterally, which project towards the midline and become splayed
|
cellular
|
• between E14.5 and E16.5, there are less apoptotic cells in the presumptive paraventricular nucleus (PVN) area in mutants than in heterozygous controls
|
|
• by E12.5, a subtle but noticeable difference in the shape of the paraventricular nucleus/supraoptic nucleus (PVN/SON) progenitor domains is observed between mutants and controls
• at E13.5, mutant cells are never found at the lateral pia surface
• at E14.5 when normal PVN and SON neurons are distinguishable in controls, mutant cells are less coherent and stay as a scattered group of cells between normal PVN and SON positions
• at E15.5, mutant cells remain mislocalized
• at P0, no mutant cells are found at normal PVN or SON positions
|
