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Phenotypes Associated with This Genotype
Genotype
MGI:3613783
Allelic
Composition
Sim1tm1Jlmd/Sim1tm1Jlmd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sim1tm1Jlmd mutation (0 available); any Sim1 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
N
• PVN/SON progenitors are generated and differentiate normally in mutant mice
• by E12.5, a subtle but noticeable difference in the shape of the paraventricular nucleus/supraoptic nucleus (PVN/SON) progenitor domains is observed between mutants and controls
• at E13.5, mutant cells are never found at the lateral pia surface
• at E14.5 when normal PVN and SON neurons are distinguishable in controls, mutant cells are less coherent and stay as a scattered group of cells between normal PVN and SON positions
• at E15.5, mutant cells remain mislocalized
• at P0, no mutant cells are found at normal PVN or SON positions
• severe defects of the paraventricular, supraoptic and anterior paraventricular nuclei are seen (J:104419)
• a slight dorsal shift of the hypothalamic Dlx1 domain is observed (J:120909)
• at E18.5, the principal mammillary axonal tract appears less prominent and contains additional axons originating laterally, which project towards the midline and become splayed

cellular
• between E14.5 and E16.5, there are less apoptotic cells in the presumptive paraventricular nucleus (PVN) area in mutants than in heterozygous controls
• by E12.5, a subtle but noticeable difference in the shape of the paraventricular nucleus/supraoptic nucleus (PVN/SON) progenitor domains is observed between mutants and controls
• at E13.5, mutant cells are never found at the lateral pia surface
• at E14.5 when normal PVN and SON neurons are distinguishable in controls, mutant cells are less coherent and stay as a scattered group of cells between normal PVN and SON positions
• at E15.5, mutant cells remain mislocalized
• at P0, no mutant cells are found at normal PVN or SON positions


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory