Phenotypes Associated with This Genotype

Genotype
MGI:3613574

• Allelic Composition: Vps54^{Gt(RRI497)Byg}/Vps54^{Gt(RRI497)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:104824 )

• embryos normal between E8.5 and E10.5

• no homozygous embryos from E12.5 onward

nervous system

absent dorsal root ganglion ( J:104824 )

• nearly completely absent at E11.5

decreased spinal cord size ( J:104824 )

• underdeveloped at E11.5

cardiovascular system

abnormal myocardial fiber morphology ( J:104824 )

• atrial and ventricular myocardium severely hypoplastic

embryo

embryonic growth retardation ( J:104824 )

• at E11.5

muscle

abnormal myocardial fiber morphology ( J:104824 )

• atrial and ventricular myocardium severely hypoplastic

growth/size/body

embryonic growth retardation ( J:104824 )

• at E11.5