Analysis Tools
behavior/neurological
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• mice exhibit a normal acoustic startle profile, prepulse inhibition, motor function, hippocampal synaptic plasticity, exploratory behavior in an open field, behavior in an elevated O maze, conditioned taste aversion, and corticosterone levels at circadian trough and peak
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• mice exhibit impaired learning of the water-maze task
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• mice exhibit deficits in measures of working memory on the radial maze
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• mice display increased horizontal and vertical exploratory activity toward a novel object that is not associated with a general increase of locomotor activity, however show a normal approach response toward the novel object
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nervous system
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• aberrant layout of the mossy fibers is seen; however, the hippocampal cornu ammonis and dentate gyrus are normal
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