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Phenotypes Associated with This Genotype
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtmr2tm1Ueli mutation (0 available); any Mtmr2 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• despite myelination abnormalities, no significant differences in compound muscle action potential amplitudes, nerve conduction velocities or F-wave latencies
• in the peripheral nerves, mutant mice exhibit a variable and complex degree of myelin infoldings and outfoldings, mainly in the paranodal regions
• defects usually are associated with large caliber axons; small caliber and non-myelinated axons appear unaffected
• defects are progressive with age; rare defects are noted at 3 weeks of age and older mice at 6 months of age tend to have more affected nerve fibers

• rarely, mutant mice exhibit a mild clasping reflex when suspended by the tail
• no other siginificant motor or strength defects were detected

Mouse Models of Human Disease
OMIM ID Ref(s)
Charcot-Marie-Tooth Disease, Type 4b1; CMT4B1 601382 J:104120

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory