Phenotypes Associated with This Genotype

Genotype
MGI:3613200

• Allelic Composition: Txnip^tm1Jjy/Txnip^tm1Jjy
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:104563 )

• vulnerable to death under fasting conditions

• 24 or 72 hours of fasting sometimes leads irreversibly to death

• condition alleviated by feeding 20% glucose during fasting but not by 10% oleic acid

homeostasis/metabolism

abnormal blood homeostasis ( J:104563 )

• during fasting

increased blood urea nitrogen level ( J:104563 )

increased circulating potassium level ( J:104563 )

decreased circulating sodium level ( J:104563 )

decreased circulating antithrombin level ( J:104563 )

• reduced antithrombin III levels

increased bleeding time ( J:104563 )

• dark red appearance in abdominal region suggestive of gastrointestinal bleeding

• observed in fasting mice

increased partial thromboplastin time ( J:104563 )

• prolonged activated partial thromboplastin time to as much as 200 seconds

increased prothrombin time ( J:104563 )

• prolonged prothrombin time

abnormal glucose homeostasis ( J:104563 )

decreased circulating glucose level ( J:104563 )

• regardless of fasting state

abnormal circulating insulin level ( J:104563 )

• insulin levels fail to become lower during fasting

abnormal lipid homeostasis ( J:104563 )

• during fasting

increased circulating ketone body level ( J:104563 )

increased circulating cholesterol level ( J:104563 )

increased circulating free fatty acids level ( J:104563 )

abnormal circulating phospholipid level ( J:104563 )

increased circulating triglyceride level ( J:104563 )

• significantly increased

hematuria ( J:104563 )

• with fasting

liver/biliary system

hepatic steatosis ( J:104563 )

• during fasting

• yellow colored liver

macrovesicular hepatic steatosis ( J:104563 )

microvesicular hepatic steatosis ( J:104563 )

liver degeneration ( J:104563 )

• during fasting

• levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase elevated

renal/urinary system

hematuria ( J:104563 )

• with fasting

kidney failure ( J:104563 )

• as indicated by elevated BUN, hyponatremia, and hyperkalemia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Reye syndrome		DOID:14525		J:104563