Analysis Tools
mortality/aging
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• animals exposed to doxycycline from E6.5 die within a few hours of birth from respiratory failure
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respiratory system
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• severely reduced density of lung capillary network in newborn animals exposed to doxycycline from E6.5, associated with reduced VEGF expression in mutant lungs
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• areas of thin lung mesenchyme and upregulation of integrin alpha 3 (Lama5 receptor) in newborn animals exposed to doxycycline from E6.5
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• areas of thin lung mesenchyme in newborn animals exposed to doxycycline from E6.5
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• total lung parenchyma is reduced
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• airspaces of newborn animals exposed to doxycycline from E6.5 are filled with amorphous proteinaceous material and cellular debris not seen in controls
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• delayed or impaired differentiation of distal alveolar epithelium in newborn animals exposed to doxycycline from E6.5
• mutant peripheral airspaces are often lined with cuboidal epithelium
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• virtual absence of alveolar type I cells in newborn animals exposed to doxycycline from E6.5
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• significant reduction of alveolar type II cells in newborn animals exposed to doxycycline from E6.5
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• enlarged distal airspaces in newborn animals exposed to doxycycline from E6.5
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• newborn animals exposed to doxycycline from E6.5 display labored breathing
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homeostasis/metabolism
cardiovascular system
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• severely reduced density of lung capillary network in newborn animals exposed to doxycycline from E6.5, associated with reduced VEGF expression in mutant lungs
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cellular
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• in lungs of newborn animals exposed to doxycycline starting at E6.5
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• in lungs of newborn animals exposed to doxycycline from E6.5
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