Phenotypes Associated with This Genotype

Genotype
MGI:3612980

• Allelic Composition: Hmox2^tm1Poss/Hmox2^tm1Poss
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:46183 )

• increased susceptibility to hyperoxia (95% oxygen), died in 8.5 days as opposed to 13.4 days

nervous system

nervous system phenotype ( J:29523 )

N • brain morphology normal and basal synaptic functions all normal in the hippocampus, long term potentiation normal

abnormal nerve fiber response ( J:89562 )

• neuronal depolarization abnormalities result in failure of enteric smooth muscle relaxation

respiratory system

abnormal respiratory system physiology ( J:46183 )

• total glutathione in lungs increased over normal levels

• glutathione levels decrease 50% after 3 days of 95% hyperoxia

• 1.3 fold increase in lung protein carbonyls after 3 days of 95% hyperoxia

• increased Hmox1 levels after 3 days of 95% hyperoxia but not to the extent seen in controls

• higher levels of nitrotyrosine than in controls, indicating damage induced by NO

homeostasis/metabolism

abnormal iron level ( J:46183 )

• significantly increased levels of lung hemoproteins after exposure to hyperoxia

• heavy iron staining of lung endothelium after exposure to hyperoxia

• less lung ferritin protein protein after exposure to hyperoxia

digestive/alimentary system

abnormal intestinal transit time ( J:89562 )

• longer gastrointestinal transit times due to failure of enteric smooth muscle to relax normally