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Phenotypes Associated with This Genotype
Genotype
MGI:3612954
Allelic
Composition
Pax9tm1Hpt/Pax9tm1Hpt
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax9tm1Hpt mutation (0 available); any Pax9 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• in 13% of mice all teeth are present but the lower incisors and third molars are hypoplastic
• in 35% of mice tooth defects differ between the right and left halves of the lower jaw
• in most cases the lower incisors are absent
• the lower first molars show significant attrition and formation of reparative and reactionary dentin
• the upper and lower third molars are unilaterally or bilaterally absent
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed
• lower third molars and incisors may fail to erupt
• a mixture of reactionary and reparative dentin seen in molars
• in 35% of mice up to 3 teeth are absent (hypodontia) and in 52% of mice 4 or more teeth are absent (oligodontia); however the secondary palate is intact and digit duplication is not seen

craniofacial
• in 13% of mice all teeth are present but the lower incisors and third molars are hypoplastic
• in 35% of mice tooth defects differ between the right and left halves of the lower jaw
• in most cases the lower incisors are absent
• the lower first molars show significant attrition and formation of reparative and reactionary dentin
• the upper and lower third molars are unilaterally or bilaterally absent
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed
• lower third molars and incisors may fail to erupt
• a mixture of reactionary and reparative dentin seen in molars
• in 35% of mice up to 3 teeth are absent (hypodontia) and in 52% of mice 4 or more teeth are absent (oligodontia); however the secondary palate is intact and digit duplication is not seen

endocrine/exocrine glands
N
• thymus morphology is normal and no signs of defective parathyroid or ultimobranchial body function (as shown by normal calcium and phosphate homeostasis) are seen

growth/size/body
• in 13% of mice all teeth are present but the lower incisors and third molars are hypoplastic
• in 35% of mice tooth defects differ between the right and left halves of the lower jaw
• in most cases the lower incisors are absent
• the lower first molars show significant attrition and formation of reparative and reactionary dentin
• the upper and lower third molars are unilaterally or bilaterally absent
• at E13.5 the size of the mesenchymal cell condensations underlying the posterior part of the dental lamina is reduced, but the dental papilla of the first molar has formed
• lower third molars and incisors may fail to erupt
• a mixture of reactionary and reparative dentin seen in molars
• in 35% of mice up to 3 teeth are absent (hypodontia) and in 52% of mice 4 or more teeth are absent (oligodontia); however the secondary palate is intact and digit duplication is not seen

Mouse Models of Human Disease
OMIM ID Ref(s)
Tooth Agenesis, Selective, 3; STHAG3 604625 J:104121


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory