Phenotypes Associated with This Genotype

Genotype
MGI:3612893

• Allelic Composition: Ntrk2^tm1Lfp/Ntrk2^tm1Lfp
• Genetic Background: involves: 129 * C57

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:104489 )

• average lifespan is 3.39 days (10 of 28 die within the first day), however those that survive past 5 days, die at an average age of 10.8 days and the maximum life span is 15 days

nervous system

abnormal somatic nervous system morphology ( J:104489 )

abnormal sensory neuron innervation pattern ( J:104489 )

• severe loss of radial fibers in the apical region of the cochlea, but less severe than in homozygous Ntrk2^tm1Bbd mice in the middle and basal turns of the cochlea

small cochlear ganglion ( J:104489 )

• 12% reduction of neuron number in cochlear ganglia

small geniculate ganglion ( J:104489 )

• 94% reduction of neuron number in geniculate ganglia

small petrosal ganglion ( J:104489 )

• 56% reduction of neuron number in nodose/petrosal ganglia

small trigeminal ganglion ( J:104489 )

• 22% reduction of neuron number in trigeminal ganglia

small nodose ganglion ( J:104489 )

• 56% reduction of neuron number in nodose/petrosal ganglia

small vestibular ganglion ( J:104489 )

• 74% reduction of neuron number in vestibular ganglia