Phenotypes Associated with This Genotype

Genotype
MGI:3612681

• Allelic Composition: Atg5^tm1Nmz/Atg5^tm1Nmz
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:104491 )

• die within one day of delivery

• die earlier compared with controls under starvation conditions after caesarean delivery (12 hours vs. 21 hours in controls), but survival can be prolonged by forced milk feeding

cellular

abnormal lysosome morphology ( J:104491 )

• autolysosomes (degrading autophagic vacuoles) absent

homeostasis/metabolism

abnormal amino acid level ( J:104491 )

• under fasting conditions, have lower amino acid levels in the heart, liver and brain 10 hours after, but not immediately after, caesarean delivery

abnormal circulating amino acid level ( J:104491 )

• under fasting conditions, have lower essential and branched-chain amino acid levels in plasma 10 hours after, but not immediately after, caesarean delivery

behavior/neurological

absent gastric milk in neonates ( J:104491 )

• no milk in stomachs of neonates, suggesting a suckling defect

cardiovascular system

abnormal ST segment ( J:104491 )

• severe elevation of the ST segment becomes apparent 8 hours after caesarean delivery under fasting conditions, however see no abnormalities in the coronary arteries or the respiratory system, suggesting a shortage of respiratory substrates and not oxygen

hematopoietic system

hematopoietic system phenotype ( J:103983 )

N • organelle degradation occurs normally in erythroid cells

vision/eye

vision/eye phenotype ( J:103983 )

N • organelle degradation occurs normally in embryonic lens cells as the formation of the organelle free zone in the lens is normal