Phenotypes for Otx2 MGI:3612483 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Otx2^{tm1(Dkk1)Imat}/Otx2^{tm1(Dkk1)Imat}
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^{tm1(Dkk1)Imat} mutation (0 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal rostral-caudal axis patterning ( J:103272 )

• based on expression of anterior visceral endoderm markers, axis rotation defects observed in Otx2^tm2/Otx2^tm2 was partially rescued (n = 20/50)

• anterior neuroectoderm is not properly induced

• mutant embryos are unable to form the anterior sesendoderm properly

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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