Phenotypes Associated with This Genotype

Genotype
MGI:3612464

• Allelic Composition: Gria2^tm2Rsp/Gria2⁺; Tg(Gria2*586N)238.2Rsp/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:51845 )

• die before P25

nervous system

seizures ( J:51845 )

• exibit periodic spontaneous epileptic seizures that start at P14/15

abnormal hippocampus CA3 region morphology ( J:51845 )

• develop neurosclerosis in CA3 subfield

abnormal AMPA-mediated synaptic currents ( J:51845 )

• calcium permeability of AMPA receptors in CA1 pyramidal neurons is increased about 4-fold relative to wild-type

• significant increase in the macroscopic AMPA receptor conductance in nucleated patches of CA1 pyramidal cells

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:51845 )

• mutants are hyperexcitable

seizures ( J:51845 )

• exibit periodic spontaneous epileptic seizures that start at P14/15