Phenotypes Associated with This Genotype

Genotype
MGI:3612461

• Allelic Composition: Tg(Gria2*586N)238.2Rsp/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:97818 )

• decreased body weight from 19 to 83 weeks

nervous system

gliosis ( J:97818 )

• reactive gliosis in the ventral horns of lumbar spinal cord, basolateral amygdaloid nucleus, and ventromedial hypothalamic nucleus

abnormal ventromedial hypothalamic nucleus morphology ( J:97818 )

• neurons in different stages of degeneration and reactive gliosis in the ventromedial hypothalamic nucleus

• decreased density of neurons in the ventromedial hypothalamic nucleus of 12- and 24-month-old mice

abnormal amygdala morphology ( J:97818 )

• neurons in different stages of degeneration and reactive gliosis in the basolateral amygdaloid nucleus

• decreased density of neurons in the basolateral amygdaloid nucleus of 12- and 24-month-old mice

motor neuron degeneration ( J:51845 , J:97818 )

• develop late motoneuron degeneration and motoneuron disease (J:51845)

• neurons in different stages of degeneration in the ventral horns of lumbar spinal cord, basolateral amygdaloid nucleus, and ventromedial hypothalamic nucleus (J:97818)

• vacuolar structures in the cytoplasm and darkening of the nucleoplasm and cytoplasm in degenerating neurons (J:97818)

• preservation of synaptic contacts onto degenerating neurons (J:97818)

abnormal spinal cord ventral horn morphology ( J:97818 )

• neurons in different stages of degeneration and reactive gliosis in the ventral horns of lumbar spinal cord

decreased spinal cord ventral horn cell number ( J:97818 )

• decreased density of neurons in the ventral horns of lumbar spinal cord of 12- and 24-month-old mice

abnormal AMPA-mediated synaptic currents ( J:51845 )

• 2-fold increase in the calcium permeability of AMPA receptors in nucleated CA1 cell patches

behavior/neurological

increased anxiety-related response ( J:97818 )

• anxiety between 19 and 75 weeks of age

• avoid the open arms of the maze, entering them less frequently and spending less time in them

• avoid punished crossings in the four-plate test

abnormal reflex ( J:97818 )

• plantar flexion first seen in 33% of the mice at 35 weeks vs 15-25% in wild-type mice at more advanced ages

• plantar flexions are progressively evident in 83% of the mice starting at 47 weeks, and persist up to the age of 83 weeks

• decreased spinal reflexes (H-reflexes and flexor reflexes) at 24 months

short stride length ( J:97818 )

• at aged 19 to 83 weeks

decreased locomotor activity ( J:97818 )

• decreased horizontal exploratory activity between 47 and 83 weeks

• move less total distance between 35 and 83 weeks

• lower average speed of movements between 63 and 83 weeks

cellular

gliosis ( J:97818 )

• reactive gliosis in the ventral horns of lumbar spinal cord, basolateral amygdaloid nucleus, and ventromedial hypothalamic nucleus