Phenotypes Associated with This Genotype

Genotype
MGI:3612383

• Allelic Composition: Gria2^tm2.1Rsp/Gria2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:51845 )

• die before P21

growth/size/body

decreased body weight ( J:51845 )

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:51845 )

• heterozygotes are hyperexcitable

seizures ( J:51845 )

• exhibit periodic spontaneous epileptic seizures that start at P14/15

nervous system

seizures ( J:51845 )

• exhibit periodic spontaneous epileptic seizures that start at P14/15

abnormal hippocampus CA3 region morphology ( J:51845 )

• neurosclerosis is observed in the lateral CA3 subfield

abnormal AMPA-mediated synaptic currents ( J:51845 )

• AMPARs have a 5-fold increase in calcium permeability in CA1 pyramidal cells and a small degree of current rectification

• significant increase in macroscopic AMPA receptor conductance in nucleated CA1 pyramidal cell patches