Phenotypes Associated with This Genotype

Genotype
MGI:3612255

• Allelic Composition: Gria2^tm2Rsp/Gria2^tm2Rsp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:51845 )

• die between P4 and P20

growth/size/body

decreased body weight ( J:51845 )

postnatal growth retardation ( J:51845 )

nervous system

abnormal hippocampus CA3 region morphology ( J:51845 )

• basal dendrites of CA3 cells are reduced in length and in number of branching points

abnormal excitatory postsynaptic potential ( J:51845 )

• require 30% higher stimulation currents to elicit fEPSPs of the same amplitude as wild-type and the number of failures to induce LTP is increased compared to wild-type

abnormal AMPA-mediated synaptic currents ( J:51845 )

• AMPA receptor currents desensitize faster and have a smaller steady-state component than wild-type

• 29-fold increase relative to wild-type in fractional calcium currents (P_f values) of AMPA receptors in CA1 pyramidal cells at a membrane potential of -60 mV, however never observe seizures

behavior/neurological

lethargy ( J:51845 )

• show stupor from P15 onward and are hypoexcitable