Phenotypes Associated with This Genotype

Genotype
MGI:3611804

• Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b⁺
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:103819 )

• similar increase in the incidence of urethane-induced lung tumors as homozygotes, with more large tumors than in wild-type

• increased incidence of liver hemangiomas, uterine tumors, and ovarian granulose cell tumors after 20 weeks of urethane treatment, but less than in homozygotes

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:103819 )

• similar increase in the incidence of urethane-induced lung tumors as homozygotes, with more large tumors than in wild-type

• increased incidence of liver hemangiomas, uterine tumors, and ovarian granulose cell tumors after 20 weeks of urethane treatment, but less than in homozygotes