Phenotypes Associated with This Genotype

Genotype
MGI:3611454

• Allelic Composition: Abcb1a^tm1Bor/Abcb1a^tm1Bor; Abcb1b^tm1Bor/Abcb1b^tm1Bor
• Genetic Background: FVBTac.129P2-Abcb1b^tm1Bor Abcb1a^tm1Bor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased double-positive T cell number ( J:102640 )

• increase in CD4+CD8+ intestinal intraepithelial lymphocytes

decreased gamma-delta intraepithelial T cell number ( J:102640 )

• intestinal intraepithelial lymphocyte development is altered such that there is an increase in lymphocytes that express CD8alpha beta markers and a decrease in lymphocytes that express TCRgamma delta

abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:102640 )

• proportion of CD8+ intestinal intraepithelial lymphocytes expressing CD8alpha beta markers rose from 5% in wild-type to 27% in mutants

• intestinal intraepithelial lymphocyte development is altered such that there is an increase in lymphocytes that express CD8alpha beta markers and a decrease in lymphocytes that express TCRgamma delta

abnormal T cell physiology ( J:102640 )

• proliferative responses of isolated intestinal intraepithelial lymphocytes are higher in response to PMA stimulation and lower than wild-type in response to anti-CD28 stimulation

increased interferon-gamma secretion ( J:102640 )

• PMA plus ionomycin stimulation results in increased IFN-gamma production by isolated intestinal intraepithelial lymphocytes compared to wild-type

increased interleukin-2 secretion ( J:102640 )

• isolated intestinal intraepithelial lymphocytes produce increased levels of IL-2

• PMA plus ionomycin stimulation results in increased IL-2 production by intestinal intraepithelial lymphocytes compared with wild-type while anti-CD28 stimulation results in decreased IL-2 production compared to wild-type

homeostasis/metabolism

abnormal xenobiotic pharmacokinetics ( J:102640 , J:107822 )

• lymph node T cells and to a lesser extent, intestinal intraepithelial lymphocytes, are impaired in extruding R-123, and efflux of R-123 is not inhibited by verapamil or reserpine as in controls (J:102640)

• bilary excretion of doxorubicin reduced by about 90% (J:107822)

hematopoietic system

increased double-positive T cell number ( J:102640 )

• increase in CD4+CD8+ intestinal intraepithelial lymphocytes

decreased gamma-delta intraepithelial T cell number ( J:102640 )

• intestinal intraepithelial lymphocyte development is altered such that there is an increase in lymphocytes that express CD8alpha beta markers and a decrease in lymphocytes that express TCRgamma delta

abnormal CD8 positive, alpha-beta intraepithelial T cell morphology ( J:102640 )

• proportion of CD8+ intestinal intraepithelial lymphocytes expressing CD8alpha beta markers rose from 5% in wild-type to 27% in mutants

• intestinal intraepithelial lymphocyte development is altered such that there is an increase in lymphocytes that express CD8alpha beta markers and a decrease in lymphocytes that express TCRgamma delta

abnormal T cell physiology ( J:102640 )

• proliferative responses of isolated intestinal intraepithelial lymphocytes are higher in response to PMA stimulation and lower than wild-type in response to anti-CD28 stimulation