About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3611211
Allelic
Composition
Psen1tm1Dgf/Psen1tm1Dgf
Tg(APPSWE)2576Kha/?
Genetic
Background
involves: 129 * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Dgf mutation (0 available); any Psen1 mutation (28 available)
Tg(APPSWE)2576Kha mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• accelerated onset of amyloid deposition in a gene-dosage dependent manner
• amyloid-beta deposition was widely distributed throughout the brain and spinal cord

homeostasis/metabolism
• accelerated onset of amyloid deposition in a gene-dosage dependent manner
• amyloid-beta deposition was widely distributed throughout the brain and spinal cord

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:102425


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/26/2016
MGI 6.03
The Jackson Laboratory