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Phenotypes Associated with This Genotype
Genotype
MGI:3611210
Allelic
Composition
Apptm1.1Cep/Apptm1.1Cep
Psen1tm1Dgf/Psen1tm1Dgf
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1.1Cep mutation (0 available); any App mutation (22 available)
Psen1tm1Dgf mutation (0 available); any Psen1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)
• amyloid-beta deposition beginning at 6 months of age (J:102425)
• deposition increased linearly over time (J:102425)

homeostasis/metabolism
• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)
• amyloid-beta deposition beginning at 6 months of age (J:102425)
• deposition increased linearly over time (J:102425)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:102425


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory