Phenotypes for Hoxa4 Hoxb4 MGI:3611204 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hoxa4^tm1Bhr/Hoxa4^tm1Bhr Hoxb4^tm1Bay/Hoxb4^tm1Bay
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa4^tm1Bhr mutation (0 available); any Hoxa4 mutation (9 available)
Hoxb4^tm1Bay mutation (1 available); any Hoxb4 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:27467 )

• died within the first week of life

skeleton

abnormal cervical vertebrae morphology ( J:27467 )

• loss of lateral articulations between C2 and C3

• large processus spinosi on both C2 and C3

• C7 rib found in Hoxa4^tm1Bhr single homozygotes is not found

• anterior tuberculi shifted from C6 to C7

cervical vertebral fusion ( J:27467 )

• fusions of C2 and C3

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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