Phenotypes Associated with This Genotype

Genotype
MGI:3611053

• Allelic Composition: Hoxb4^tm1Bay/Hoxb4^tm1Bay; Hoxd4^tm1Bhr/Hoxd4^tm1Bhr
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:27467 )

• most homozygotes die within the first week of life but small numbers survive past six months

skeleton

abnormal cervical vertebrae morphology ( J:27467 )

• neural arches of C1 and C2 are often fused

cervical vertebral transformation ( J:27467 )

• almost complete C2 to C1 transformation

• C3 to C1 and C3 to C2 transformations

• C6 to C5 and C7 to C6 transformations

fusion of vertebral arches ( J:27467 )

• neural arches of C1 and C2 are often fused