Phenotypes Associated with This Genotype

Genotype
MGI:3611046

• Allelic Composition: Tg(PDGFB-APPSweIndArc)48Lms/0
• Genetic Background: B6.Cg-Tg(PDGFB-APPSweIndArc)48Lms

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:100954 )

• by 2 months of age, mice have many neuritic plaques

• mice develop striking parenchymal plaques but show no obvious increase in cerebrovascular amyloid deposition compared to Tg(PDGFB-APPSwInd)20Lms mice

abnormal neuron morphology ( J:100954 )

• dystrophic neurites are associated with plaques

homeostasis/metabolism

amyloidosis ( J:100954 )

• at 2-4 weeks, mice have 2.2-3.5-fold higher Abeta(1-x) levels compared to Tg(PDGFB-APPSwInd)20Lms or Tg(PDGFB-APPSweIndArc)6Lms mice

amyloid beta deposits ( J:100954 )

• by 2 months of age, mice have many neuritic plaques

• mice develop striking parenchymal plaques but show no obvious increase in cerebrovascular amyloid deposition compared to Tg(PDGFB-APPSwInd)20Lms mice