Phenotypes Associated with This Genotype

Genotype
MGI:3611045

• Allelic Composition: Tg(PDGFB-APPSweIndArc)6Lms/0
• Genetic Background: B6.Cg-Tg(PDGFB-APPSweIndArc)6Lms

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:100954 )

• in 5-12 month old mice, Abeta peptide deposits are observed, with higher Abeta(1-38)/Abeta(1-40) ratio and lower Abeta(1-42)/Abeta(1-40) ratio than Tg(PDGFB-APPSwInd)20Lms-expressing mice

• plaque formation occurs earlier and is more extensive than in Tg(PDGFB-APPSwInd)20Lms mice

• mice have more plaques than Tg(PDGFB-APPSwInd)20Lms mice at 6-7 months of age

• mice develop striking parenchymal plaques but show no obvious increase in cerebrovascular amyloid deposition compared to Tg(PDGFB-APPSwInd)20Lms mice

abnormal neuron morphology ( J:100954 )

• dystrophic neurites are associated with plaques

• mice have more dystrophic neurites than Tg(PDGFB-APPSwInd)20Lms mice at 6-7 months

homeostasis/metabolism

amyloid beta deposits ( J:100954 )

• in 5-12 month old mice, Abeta peptide deposits are observed, with higher Abeta(1-38)/Abeta(1-40) ratio and lower Abeta(1-42)/Abeta(1-40) ratio than Tg(PDGFB-APPSwInd)20Lms-expressing mice

• plaque formation occurs earlier and is more extensive than in Tg(PDGFB-APPSwInd)20Lms mice

• mice have more plaques than Tg(PDGFB-APPSwInd)20Lms mice at 6-7 months of age

• mice develop striking parenchymal plaques but show no obvious increase in cerebrovascular amyloid deposition compared to Tg(PDGFB-APPSwInd)20Lms mice