Mouse Genome Informatics
hm
    Ldlrap1Gt(OST149604)Lex/Ldlrap1Gt(OST149604)Lex
involves: 129S5/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• 1.8-fold increase in plasma total cholesterol levels, however plasma lipoprotein is normal
• elevation of total cholesterol is attributed to a six-fold increase of LDL cholesterol
• in vivo clearance of 125I-LDL from circulation is retarded, uptake of DiI-labled LDL by hepatocytes is decreased, and uptake of 3H-CE-labeled LDL by the liver is lower compared to wild-type, indicating decreased in vivo catabolic rate of LDL, however uptake of LDL by primary cultured hepatocytes in vitro is no different from wild-type

Mouse Models of Human Disease
OMIM IDRef(s)
Hypercholesterolemia, Autosomal Recessive; ARH 603813 J:102291