Phenotypes Associated with This Genotype

Genotype
MGI:3610561

• Allelic Composition: rg/rg
• Genetic Background: involves: AKR/J * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:4427 )

• where classification is possible, fewer mutants are seen than expected

pigmentation

head blaze ( J:64252 )

white spotting ( J:64252 )

• not consistently seen on a mixed genetic background

belly spot ( J:64252 )

hearing/vestibular/ear

abnormal inner ear morphology ( J:4427 )

• hearing is not affected

abnormal semicircular canal morphology ( J:4427 )

• constrictions always are found in the lateral ducts; sometimes in the superior or posterior ducts, or both

• condition is not necessarily bilateral

abnormal membranous labyrinth morphology ( J:4427 )

• progressive thinning of epithelium and loss of hair cells of the macula begins at 52 days

• by 150 days the entire sensory epithelium has degenerated

vestibular saccular macula degeneration ( J:4427 )

• the macula of the saccule degenerates but the organ of Corti remains normal

limbs/digits/tail

abnormal tail morphology ( J:4427 )

kinked tail ( J:4427 )

• most noticeable in newborn; frequently only palpable in the adult

behavior/neurological

jerky movement ( J:4427 )

hyperactivity ( J:4427 )

stereotypic behavior ( J:4427 )

bidirectional circling ( J:4427 )

integument

head blaze ( J:64252 )

white spotting ( J:64252 )

• not consistently seen on a mixed genetic background

belly spot ( J:64252 )